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Both have their place

Likewise, concanavalin A (Con A) induced liver injury may be also mediated by GSDME upon GzmB cleavage 33

Aescin, particularly in combination with PTU, demonstrated superior efficacy compared to rutin or PTU monotherapy

Whether this hypothesis is correct or whether accessible disulfides (e.g., within an extended loop or a flexible N- or C-terminus) circumvent such steric limitations remains to be analyzed