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Abstract Background: For many drugs, steady-state concentration-time profiles are often not optimally characterised by the intrinsic terminal elimination half-life for various reasons, including multiexponential disposition with minimal contribution of the terminal phase to steady-state exposure or use of controlled-release formulations with extended zero- or mixed zero-/first-order absorption

[56] [57] [58] One study found that gestational sleep apnea was associated with low reading test scores in children and that this effect may be mediated by an increased risk of the child having sleep apnea themselves

is supported by a Federal Government Belgium grant, long-term structural Methusalem funding by the Flemish Government, a Concerted Research Activities Belgium grant, grants from the FWO, Foundation against Cancer and ERC Advanced Research Grant