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Proposed mechanisms include regulation of endothelial function, influence on blood vessel formation, modulation of inflammatory signaling, and effects on connective tissue-associated processes such as collagen organization

In vitro and in vivo models, it was found that in the IDH1 mutant glioma cells intervened by triptolide, the transcriptional activity of Nrf2 was suppressed, and the expressions of GCLC, GCLM and SLC7A11 were down-regulated, thereby disrupting the metabolism of glutathione