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Pajares MI, Rojo A, Manda G et al (2020) Inflammation in Parkinsons disease: mechanisms and therapeutic implications

Even during the prodromal period, when LRRK2 expression in the colon is noticeably raised, increased expression of LRRK2 has been observed in colon biopsies from PD patients, with expression levels corresponding with disease severity (98)

These are separate issues that require separate analysis

coli mutant strains were cultivated in 750 L MOPS minimal medium in a transparent 48-well plate (Sarstedt, Nmbrecht, Germany) without or with supplementation of 5 mM GSH or GSSG at 37 C with continuous shaking in an infinite M200 multiplate reader (Tecan instruments, Mnnedorf, Switzerland)