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Modeling of Target Protein Structures The 3D structure files of the breast cancer biomarkers estrogen receptor (PDB:1QKU), progesterone receptor (PDB:2OVH), human epidermal growth factor receptor (PDB:3GOP), mind bomb (Mib) protein (PDB:4TSE), and Ki-67 (PDB:5J28) were then obtained from Protein Data Bank25 (Figure 2

This subcluster was predominantly located in severely degenerated cartilage regions and interacted frequently with regenerative clusters (C1-2, C1-4, C2), implying that ferroptotic cells may impair cartilage repair through paracrine effects