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The collagen type II staining intensity was scored using ImageJ (version 1.53t, National Institutes of Health, Bethesda, MD, USA), as follows: 0 (negative), 1 (weakly positive), 2 (moderately positive), and 3 (strongly positive)

The iron chelators deferoxamine (DFO), ciclopirox olamine (CPX), and EDTA were used as the positive control

Although it closely resembles hyperpigmentation, most discoloration in intimate areas is actually the result of hyper-friction from coarse hair, tight clothing, or skin rubbing against other skin

They are not only effective in addressing various skin imperfections, including: Acne scars