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For instance, recent studies have proposed a CRISPR-Cas9 based tool containing a deactivated Cas9 (dCas9) nuclease fused with a catalytic domain of DNMT and combined with co-expressed sgRNA, which achieves precise DNA methylation for specific targeted regions that are heritable across mitotic divisions in daughter cells [332, 333]

Data availability The RNA-seq data used in this study were previously generated and published in our prior work 14

FIGURE 4 APC (adenomatous polyposis coli) encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway

Wang F., Sun Z., Peng D., et al., Celltherapy for Parkinson's Disease: A Systematic Review and Metaanalysis, Journal of Translational Medicine 21, no