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As it is well established that a leaky barrier characterized by increased tight junction permeability is a hallmark of pathological conditions including CRC, proteins involved in tight junction structure represent an effective target for the evaluation of gut barrier status

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As glutathione can improve the numbers and activity of macrophages, peptic ulcers may be exacerbated [40] Increased susceptibility to melanoma: Theoretically, long-term administration of systemic glutathione switches eumelanin to pheomelanin, and may increase the susceptibility towards development of melanoma in the long run

Gastroenterology Rev 2023;18: 1-42