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These transform ribulose 5-phosphate into: ribose 5-phosphate, and xylulose 5-phosphate, respectively

Consistent with these in vitro findings, co-immunoprecipitation assays in G2-synchronized HeLa cells revealed that Myc-tagged Pds5B associated with wild-type Sororin-GFP, but not with the phospho-mimetic Sororin-S145E-GFP mutant (Supplementary Fig

By integrating autophagy regulation with drug intervention, we can disrupt the favorable conditions autophagy provides for malignant cells, and circumvent its metabolic reprogramming adaptation strategy, thereby enhancing the sensitivity of AML cells to existing treatments