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Furthermore, with age, the efficiency of the DNA Damage Response in eukaryotes, which is responsible for preventing the replication of damaged DNA, also declines (Zhu et al., 2024)

After being fed HFD for a total of 16-weeks (an appropriate rodent model of DIO and comparable to human obesity) and reaching pre-arrival body weights (38 g), mice were randomized into balanced control and treatment cohorts (n=9/cohort), with similar group average body weight and standard deviation