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38,39 These failures may be attributed in part to flaws in study design, such as imbalance in patient baseline across treatment arms and lack of specific participant eligibility criteria, but may also be due to the structure of the agents themselves being less active in humans and presenting off-target toxicity

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An 18-month study in mice and a lifetime study in hamsters revealed no evidence of tumorigenicity

Thats because most skincare products work only on the surface, while your skin concerns like pigmentation, dullness, and uneven skin tone often begin much deeper, at a cellular level