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Description

SR 141716, better known as Rimonabant, is an inverse agonist at the type-1 cannabinoid receptor (CBR1), and thus belongs to the first pharmacological category of nootropics

It was discovered more than 30 years ago, and in all that time, not one controlled human trial of it has been published

Demyelination peaks between 4.5 and 5 weeks of cuprizone exposure in the CC and between 5 and 6 weeks in the cortex and hippocampus (Hiremath et al., 1998