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Safety and immunogenicity of a novel multivalent OspA-based vaccine candidate against Lyme borreliosis: a randomised, phase 1 study in healthy adults

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It seems likely that the spike in IL-6 , secreted by the macrophages responding to the viral entry, triggers NETosis in the patients with severe COVID-19, leading to a complex interaction among NETosis, complement and coagulation pathways [18], pulmonary immune thrombosis and acute respiratory distress

In a double-blind, placebo-controlled randomized trial, Hendouei and colleagues evaluated resveratrol (non-botanical resveratrol