l carnitine ejection fraction a) l‐Carnitine treatment improves right ventricular Normal Hearts Pump Out 50-70%

Metformin, involved in the metabolic reprogramming of tumor cells, can downregulate glycolysis and inhibit cancer growth, but its therapeutic efficacy is limited in hypoxic microenvironments (Granja et al., 2015)

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Studies on animals with high uric acid levels revealed that quercetin treatment restored these enzyme activities, which oxidative stress usually suppresses [2]

Specifically, overexpressed GPX3 induced mitochondrial dysfunction and cytoplasmic transfer of Cyto-C through up-regulation of BAX and down-regulation of Bcl-2, and ultimately induced mitochondria-dependent apoptosis via the caspase 9-caspase 3 cascade, and then cooperated with the blocking effect of GPX3 on G0/G1 phase to attenuate the proliferation activity of prostate cells