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81 Notably, Wnt5a, a common nonclassical Wnt pathway activator, after secretion by fibroblasts, activates the classic Wnt signalling pathway in AT2 cells and inhibits the transdifferentiation of AXIN2 + AT2 cells with stem cell activity into AT1 cells, thus maintaining the dryness of AT2 cells

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The initial concentration of acetate is obtained from the neutralization reaction: The equilibrium reaction of acetate with water is as follows: The equilibrium constant for this reaction is K b = K w / K a , where K a is the acid ionization constant of acetic acid

These results demonstrate that GPX4 and Vitamin E can finely tune the lipid redox balance in HSCs, thus preventing them from ferroptosis