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Development of peptide therapeutics: A nonclinical safety assessment perspective

Out of the three options, Thesis has an edge here because it uses some shorter lists of ingredients in doses that are sometimes lower than what human studies confirm to be effective

In physical dependence assay (isoniazid challenge assessed at 6, 14, 42 and 72 h after conditioning medication), when compared to diazepam non-conditioned healthy mice, in diazepam conditioned mice residual anticonvulsive activity was not present already at the earliest post-conditioning interval (i.e., not different latency to isoniazid-convulsions), whereas shorter preconvulsive latencies (as physical dependence/withdrawal hallmark) were noted in diazepam conditioned mice following isoniazid challenge at 42 h and at 72 h after end of conditioning treatment

NMR in biomedicine, 21 (10), 10661075