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while the noval approach include the detoxification using nanoparticals, plant extracts, pulse electric field (PEF), uning omics studies, etc

Cummings et al., 2019

Mechanistically, BMI1 directly bound to the promoter of MAPK phosphatase 1 (MKP-1, also known as DUSP1) to suppress its expression

(ref) Seiwerth S, Sikiric P, Grabarevic Z, Zoricic I, Hanzevacki M, Ljubanovic D, Coric V, Konjevoda P, Petek M, Rucman R, Turkovic B, Perovic D, Mikus D, Jandrijevic S, Medvidovic M, Tadic T, Romac B, Kos J, Peric J, Kolega Z