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As for the other PDEs, 18 showed no inhibition towards PDE1-3, PDE4 and PDE7-10 at screening doses of 20 M, 10 M and 3 M, respectively [240]

doi: 10.1021/acsnano.1c11016

The Role of P53 in Cancer Drug Resistance and Targeted Chemotherapy

In future, researchers need to focus on dynamic multi-omics risk assessment systems and network medicine-based multi-target intervention strategies to stimulate the translation from molecular mappings to clinical applications