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Absorb Every Drop: Ideal for those with MTHFR mutations or gut issues who can't process synthetic B12

14 Because O 2 is an obligatory substrate for PHDs, HIFs escape PHD-dependent hydroxylation under hypoxic conditions, translocate to the nucleus and dimerize with the subunit (also termed ARNT), and through binding to hypoxia-response elements in promoter regions of target genes, activate the transcription of its target genes (Figure 1)