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The groups were matched to the best of the researchers abilities, given the limited sample size, and the study was performed in a double-blind crossover manner with a one week washout period

10.3390/ijms23116196 108

[15] Although a large burst of ROS is known to lead to cell damage, a moderate release of ROS from the mitochondria, which occurs during nonlethal short episodes of ischemia, can play a significant triggering role in the signal transduction pathways of ischemic preconditioning leading to reduction of cell damage