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In the asthmatic animals, there was a reduction in contractile efficacy in the presence of indomethacin (approximately 82% reduction compared to the absence), without changes in potency, indicating that in this asthma induction model, inhibition of this enzyme resulted in reduced production of contractile prostanoids, such as PGD 2 and PGF 2 (Figure 2

Inhibition of collagen secretion from bone and cultured fibroblasts by microtubular disruptive drugs

On the other hand, pro-oxidant (Lorza-Gil et al., 2016

The treated group showed a lower expression of angiogenic markers like VEGF, fibroblast growth factor (FGF), and VEGFR2