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Elevated homocysteine levels have been linked to traumatic brain injury (TBI) as well, which confers a greater risk for developing AD than stroke (Rahmani et al., Causes of Hyperhomocysteinemia Homocysteine can be consumed by either its conversion to methionine by the transmethylation pathway or by its conversion to cysteine via the reverse transsulfuration pathway (Figure 1)

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46,47 Furthermore, compared to people without depression, patients with MDD have been demonstrated to have a shorter life expectancy

In addition, sustained DAMP-mediated signalling can sustain NF- and inflammasome activation, sustaining elevated levels of inflammatory cytokines at all times because of elevated levels of basal inflammatory cytokines and their release even in the absence of any initiating cause, effectively relating pulmonary inflammation with systemic effects [35]