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Ligand binding activates adenylyl cyclase, elevating intracellular cAMP and triggering PKA-mediated phosphorylation of downstream steroidogenic targets including CYP11A1, CYP17A1, and 3-HSD

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Use a cloth or towel to cover the ice pack and apply it for 15-20 minutes at a time, several times a day

As the antigen continues to interact with antibodies throughout the body, the fourth and final event occurs: The patient demonstrates an outward response to the mediators (i.e