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2 The mechanism and regulation pathways of ferroptosis Ferroptosis is an iron-dependent form of programmed cell death, characterized by uncontrolled accumulation of lipid peroxidation, leading to disruption of cell membrane structure and cell death ( 2.1 Core driving role of iron metabolism As a core driver of ferroptosis, iron deeply participates in the cascade reaction of ferroptosis through its unique redox activity and metabolic network ( + is endocytosed, converted to Fe + by reductases such as STEAP3 in acidic endosomes, and then transported to the cytoplasm through DMT1 to form a labile iron pool (LIP)