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225,241 Relevant mechanisms can be explained as enhancing anti-phagocytosis and activating the proinflammatory NLRP3 pathway

This reduced binding affinity may be attributed to a subtle mismatch between part of the suramin molecule and the MARV polymerase binding pocket, or to the absence of the other half of the suramin molecule in the EBOV polymerase structure (PDB: 7YET), which might hinder effective binding to the MARV polymerase

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Therefore, a true overdose that causes toxicity is extremely rare