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SAAR reduces glyoxalase cycle intermediates and associated protein PTMs To further explore the potential connectivity between serine synthesis and GSH availability, we assessed markers of glyoxalase cycle metabolism (Fig

J Neurochem 1995;20:1465-70

Exogenous pathways rely on the inhibition of system Xc (cystine/glutamate transporter) and the activation of the transferrin and transferrin receptor 1, while the endogenous pathway mainly involves blocking the activation of GPX4 (Xue et al., 2023)

Other rodent models also corroborate a salutary response to GABA in diabetes(median dose 1500 mg/kg/day, range 0.25-4500) (4452)