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Iron overload impairs normal hematopoietic stem and progenitor cells through reactive oxygen species and shortens survival in myelodysplastic syndrome mice

The formation of MCSs is mediated by tether proteins that bring membranes close to each other via protein-protein and/or protein-membrane interactions (Levine and Loewen, 2006

Relative amounts of the therapeutic agent, the excipient and/or any additional ingredients in a pharmaceutical formulation may vary, depending on the subject size, condition of the subject treated, and/or by the route of administration of the pharmaceutical formulation

The latters, in turn generate both RCS and ROS (33), leading to new stages of glycoxidation, creating more and more vicious nonenzymatic chemical cycles (Figure 1, red arrows)