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If the stress is too severe or prolonged, the UPR can shift from a protective role to triggering apoptosis, in order to eliminate the affected cell and prevent damage (Spencer and Finnie, 2020)

The NF-B-modulated miR-19a-3p enhances malignancy of human ovarian cancer cells through inhibition of IGFBP-3 expression

Mattei AL, Bailly N, Meissner A

Ni-enzymes are most widely used in anaerobic Bacteria and Archaea, which reflects the fact that Ni was prevalent in ancient environments (Hausinger, 2022)