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While its oxidized form has a pro-oxidant effect, its reduced form (GSH or L-glutathione) constitutes a first-line defense for cells (2)

DOI: 10.1371/journal.pone.0136541

Thus, in terms of development of transporter-utilizing prodrugs for delivery to the brain, it is essential to understand the mechanism of BBB permeation, intra-brain distribution and release of parent drug from prodrug at the target site within the brain (Fig