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Sullam, University of California, San Francisco, UNITED STATES Received: January 2, 2020

Figure 3 shows the dose response characteristics of NAC, metformin (Met), lonidamine (LND), honokiol (HNK), and atovaquone (ATO) and the TPP + -modified analogs in MiaPaCa-2 cells 18,34,35

4.3 Creating potassium/calcium channels by ORF3a One of the important capabilities of the viral ORF3a protein is the ability to create ion channels that decrease the concentration of K i + and increase Ca i 2+ in the cell ( i + concentration leads to decreased membrane potential, which can activate voltage-dependent calcium channels (VDCCc) (283, 284), which further increases Ca i 2+ , and one of the possible effects is the activation of calcium-activated potassium channels (KCa), which further decreases K i + concentration (285)