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In conclusion, these emerging therapeutic approaches offer significant potential for cancer treatment, with lysosomal addiction-based therapies potentially becoming integral components of personalized medical strategies

Alcohol promotes the production of ROS in various ways: 1) stimulating cytochrome P450s activity, 2) altering certain metal concentrations, 3) decreasing the antioxidants level, 4) directing the conversion of xanthine dehydrogenase (XDO) into xanthine oxidase (XO)

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Therefore, regardless the clinical heterogeneity or underpinning genetics, the different forms of PD share a common etiology in mitochondrial dysfunction and oxidative stress