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As mechanisms to dispose of both hydrogen peroxide and lipid hydroperoxides are essential to life, this indicates that in contrast to the multiple metabolic pathways that can be utilized to dispose of hydrogen peroxide, pathways for the disposal of lipid hydroperoxides are limited

In the realm of clinical trials, statins such as simvastatin (MS-STAT2 trial, NCT03896217) for MS and atorvastatin (NCT00356473, NCT04177173) for RA have demonstrated the potential to reduce disease activity and slow progression (241, 242)

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Data availability Computer code for LSA, parameter estimation, numerical simulations, and GSA with PRCC was implemented in and run with the programming and computation software MATLAB (MathWorks Inc., Natick, MA, USA)