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Specifically, CD4 T cells show lower efficacy in recognizing EBV-transformed B cell lines that expressed HLA-DR15 (121, 122)

260,261 These changes amplify inflammation triggered by environmental insults such as cigarette smoke, while accelerated cellular aging (e.g., telomere shortening in alveolar cells) further drives oxidative stress and apoptosis

Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing

Zeng HY, Zhu XA, Zhang C et al (2005) Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice