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The phenylalanine (FF) residues facilitated macrophage uptake of LP-NP, while the negatively charged aspartate (D) residues prevented endosomal acidification

Trends Biochem Sci 35:505513 Heitzer T, Finckh B, Albers S, Krohn K, Kohlschutter A, Meinertz T (2001) Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress