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At 24 h after APAP exposure, GST/ and NQO1 protein levels were significantly elevated in Dox and Dox/APAP groups (Fig

Together these results suggest that ORF3a induces mROS production to activate HIF-1, which in turn triggers a shift in cellular metabolism to favor glycolysis, resulting in increased viral replication and transcription of pro-inflammatory cytokines

Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study