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Activating Transcription Factor 3 (ATF3), a member of the ATF/Cyclic AMP Response Element-Binding protein (CREB) transcription factor family, plays a crucial role in transcriptional repression and promotion with a dual function of regulating cell apoptosis, proliferation, and the cell cycle

daily for 12 days) and TQ (20 mg/kg, p.o., three alternative days/week for 12 days) exerted chemopreventive efficacy by improving antioxidant status (GSH, GST, GPx, and SOD), downregulating expressions of Bcl-2, c-fos, and PCNA and by inhibiting epidermal growth factor receptor (EGFR)/extracellular signal-regulated kinase (ERK)1/2 signaling pathway [117]