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Recent studies have shown that, in mammalian cells, most of the activesite disulphides in the ER oxidoreductases are reduced under normal steadystate conditions (Jessop & Bulleid, 2004)

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10.1016/j.dnarep.2005.07.001 18 CuiY.KnigJ.BuchholzJ

In gastric cancer cells, MR activates BNIP3 gene expression by downregulating lncRNA PVT1 expression and interacting with DNMT3, thereby activating mitophagy and inducing cell death (41)