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Furthermore, in vivo and in vitro data indicated that PPAR activation restored Pink1/Parkin-dependent mitophagy, improved mitochondrial function, inhibited chondrocyte ferroptosis, and delayed the progression of OA

Compounded drugs do not go through the same FDA review for safety, effectiveness and quality as approved medications

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GPX4KO CAOV3 cells resuspended in PBS exhibited markedly impaired intraperitoneal growth compared with WT cells, whereas GPX4KO cells resuspended in ascites displayed tumor growth comparable to WT cells, demonstrating that ascites directly suppresses ferroptosis in vivo (Fig