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Additionally, coagulation factors have post-translational modifications (PTMs) and are produced at levels comparable to those in primary hepatocytes

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Blocking the HGF/c-Met/mTOR signaling pathway by knocking down the expression of mTOR inhibits PNI of pancreatic cancer To further understand the role of mTOR in the progression of the HGF/c-Met pathway promoting PNI in pancreatic cancer, the lentiviral vector mTOR-shRNA was used to suppress mTOR expression in pancreatic cancer cell lines