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31 Phenformin has been reported to exhibit anti-thiamine activity in animals, 3234 and as a result, it has been suggested that a possible anti-thiamine effect of metformin might contribute to some cases of metformin-associated lactic acidosis, a rare condition, but one that has been shown to have a mortality rate of 1825%

Antioxidants & redox signaling 13 , 769781 (2010)

J Basic Appl Zool 81(2020):114 Hansen N, Widman G, Witt JA, Wagner J, Becker AJ, Elger CE, Helmstaedter C (2016) Seizure control and cognitive improvement via immunotherapy in late onset epilepsy patients with paraneoplastic versus GAD65 autoantibody-associated limbic encephalitis