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Studies suggest that HMB may effectively mitigate proteolysis associated with cachexia because of its capacity to reduce the activity of the ubiquitin-proteasome system, the main pathway for protein degradation and caspase activity (Prado et al., 2022)

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Lon-COVID/PASC: virus-induced human metabolic reprogramming and dysregulation (HMRD) Several recoverees or survivors of COVID-19 ( RT-PCR negative for SARS-CoV-2) continue to exhibit a plethora of clinical symptoms with impairment(s) of multiple organ systems