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The overexpression of G6PD in Drosophila melanogaster protects against oxidative stress and can also expand their lifespan (Nbrega-Pereira et al., 2016)

NRF2 has also been shown to play an important role in overseeing mitochondrial biogenesis and metabolism, although direct confirmation of target genes involved in these processes has been lacking (Dinkova-Kostova and Abramov, 2015)

In this review, we summarize the potential impact and regulatory mechanisms of ferroptosis on diabetes and its complications, as well as inhibitors of ferroptosis in diabetes and diabetic complications

This age-dependent amplification of Hcy toxicity is driven by the progressive upregulation of the MARS1-HTL-K-Hcy axis during natural aging: elevated MARS1 in mid-old endothelial cells boosts HTL synthesis and KHcy modification of proteins HMGB1/2