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Similar content being viewed by others Background Epigenetic modifications is the ensemble of mechanisms of concurrent chromatin modification to modulate global patterns in gene expression and phenotype in a heritable manner, without affecting the DNA sequence itself, which can be classified into DNA modifications (methylation and hydroxymethylation) [1], (PTMs) [2], exchange of histone variants (e.g., H1, H3.3, H2A.Z, H2A.X) [3], and as non-coding RNA [4]

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Hence, a balanced mitochondrial dynamics is pivotal in preserving insulin sensitivity and preventing the deleterious effect of lipid overload on mitochondrial bioenergetics in skeletal muscle and possibly other tissues such as the hypothalamus and the liver

Here, we aimed to elucidate how BS influences cellular and murine aging