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Drug Interactions for Depakote Effects Of Co-Administered Drugs On Valproate Clearance Drugs that affect the level of expression of hepatic enzymes, particularly those that elevate levels of glucuronosyltransferases (such as ritonavir), may increase the clearance of valproate

Besides its role in canonical TCA-cycle activities, KG is also an obligatory co-substrate of KG-dependent dioxygenases, a family of around 70 enzymes that are involved in a range of cellular activities 25 , including epigenetic regulation