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Physical properties of sodium thiosulfate pentahydrate Property Value refractive index, n d 1.4886 density, d 20 4 1.750 heat of solution in water at 25 C (kcal/mol) - 11.3 heat of formation (kcal/mol) -621.9 heat of fusion (kcal/mol) 11.85 specific heat at 21 C (cal/g) 0.346 cryoscopic constant 42.6 dissociation pressure (mm Hg) at 20 C 6.0 at 35 C 18.0 vapour pressure of saturated solution (mmHg) at 33 C 10.0 at 57 C 42.0 at 90 C 233.0 25 20 density of aqueous solution, d 20 , (Na 2 S 2 O 3 , by weight) 10% 1.0847 20% 1.1760 30% 1.2762 40% 1.3851 From: Kirk-Othmer (1969) 3.4 Synthesis Sodium thiosulfate can be produced commercially by a number of methods, of which the four principal processes may be classified as follows (Kirk-Othmer, 1969)

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subcutaneous or intramuscular Subcutaneous (SQ or SC) Injections Subcutaneous injections place medication into fatty tissue beneath the skin