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It is one of the very few animal peptides to contain a D-amino acid (D-alanine at position 2), an unusual feature that is generated post-translationally by enzymatic conversion of an L-alanine encoded in the gene [2]

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Conclusion Evidence has shown that NNMT plays important roles in obesity and T2D and that NNMT inhibition significantly increases energy expenditure, reduces body weight and white adipose mass, improves insulin sensitivity, and normalizes glucose tolerance and fasting blood glucose levels

The goal of adding GH secretagogues is shifting the weight loss composition toward fat loss and away from muscle loss, not preventing weight loss