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Activation of IGF signaling pathways promotes the growth, metastasis, and drug resistance in many types of human tumors, including mesenchymal, epithelial, and hematopoietic cancer [11,12,13]

Abstract Pediatric low-grade gliomas represent the most common childhood brain tumor class

In peritumoral hepatic tissues, the core clock genes exhibited phase advances relative to those in healthy controls, while renal tissues displayed phase delays, suggesting that tumor-derived signals disrupt clocks in distal organs (139)

Woelfel S, Silva MS, Stecher B (2024) Intestinal colonization resistance in the context of environmental, host, and microbial determinants