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Development of appropriate therapeutic strategies to complement the assessment of sperm DNA damage is very much essential for the treatment of patients with male infertility as DNA damage in the male germ line is a major risk factor for adverse clinical outcomes including poor fertilization, impaired development of the pre-implantation embryo, miscarriage and an increased risk of morbidities and mortality in the offspring

Our analysis further demonstrated that SOF, combined with the NS5A inhibitors, was well-tolerated and highly effective in patients with cirrhosis

There was a significant improvement of penile curvature at 12 weeks but results at 36 weeks were not significant

28 van den HeuvelJ