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doi: 10.1007/s00011-025-02025-4 158 JuXChenZGaoLChenMWangQJiangZ

Hydroxyl radical ( OH) is taken into account as the most potent oxidant which, owing to its short half-life, very positive redox potential (close to +2 V) and high affinity for biomolecules, non-selectively oxidize DNA, proteins, lipids, amino acids, sugars, and metals, leading to damage or genetic instability

ER proteostasis and ER-unfolded protein response (UPR) capacity are reduced under ER reductive stress, thereby promoting senescence

Gahete 1,2,3,4 , (1)Maimnides Institute of Biomedical Research of Crdoba (IMIBIC), 14004-Crdoba, Spain., (2)Department of Cell Biology, Physiology and Immunology, University of Crdoba, 14004-Crdoba, Spain., (3)Reina Sofa University Hospital (HURS), 14004-Crdoba, Spain., (4)Ciber Pathophysiology of Obesity and Nutrition (CIBERobn), Crdoba, Spain, (5)Department of Hepatology and Liver Transplantation, Reina Sofa University Hospital, 14004- Crdoba, Spain., (6)Ciber Hepatic and Digestive Diseases (CIBERehd), Crdoba, Spain Background: Hepatocellular carcinoma (HCC) genetic and transcriptomic signatures have been widely described