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doi: 10.1128/aac.01445-09 453 WijnantsS.VreysJ.Van DijckP

Immunity 56 , 20212035.e8 (2023)

Agnuside, from the extract of Vitex negundo , reduces the expression of key inflammasome components, including NLRP3, caspase-1, and ASC, along with downstream inflammatory cytokines IL-1 and IL-18 and has been effective in alleviating synovitis and fibrosis in knee osteoarthritis models [61]

Ethics statement The animal protocol was specifically approved by the Scientific Ethics Committee of Ethics Committee of the School of Public Health, Jilin University (approval No